DNA ligases seal five′-PO4 and three′-OH polynucleotide finishes by way of a few nucleotidyl transfer methods involving ligase-adenylate and DNA-adenylate intermediates. DNA ligases are vital guardians of genomic integrity, and ligase dysfunction underlies human genetic ailment syndromes. Crystal structures of DNA ligases certain to nucleotide and nucleic acid substrates https://ernestm012bvp8.robhasawiki.com/user