The interfacial residues are really conserved among eIF2α kinases and mutagenesis implicates the BTB dimer in PKR function18. FRET measurements exhibit the kinase domains dimerize when PKR binds to activating dsRNAs19. https://sahiloiey792959.wikiitemization.com/4459940/5_tips_about_pkrrating_you_can_use_today