Pentobarbital will lessen the level or influence of fedratinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Impact of coadministering a robust CYP3A4 inducer with fedratinib has not been analyzed. Barbiturates can induce hepatic microsomal enzymes causing amplified metabolism and diminished anticoagulant response of oral anticoagulants (eg, https://titusevkwh.blogitright.com/31071257/what-does-nembutal-and-seconal-are-both-examples-of-mean