Environmental or self-antigens and homotypic interactions cause BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other alerts within the microenvironment and rising the activation of anti-apoptotic and proliferation pathways.31,32 Genomic scientific studies have discovered recurrent mutations in genes regulating tumor cell-microenvironment interactio... https://buckminsterp541ksb8.develop-blog.com/profile