To investigate the role of DNA topoisomerases in transcription. we have studied global gene expression in Saccharomyces cerevisiae cells deficient for topoisomerases I and II and performed single-gene analyses to support our findings. The genome-wide studies show a general transcriptional down-regulation upon lack of the enzymes. which correlates with gene activity but not gene length. https://www.ealisboa.com/limited-stock-Purple-House-Arrethe-Bush-Balm-Soap-quick-super/