There's a launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-two-receptors inside the dorsal horn to decrease afferent pain transmission and generate analgesia. As a result, drugs like clonidine that target alpha-2 receptors can impact the transmission of discomfort. Applies to clonidine: oral tablet, oral https://www.proleviate.com/post/the-new-pain-killer-conolidine